Global sequence diversity of the lactate dehydrogenase gene in Plasmodium falciparum
نویسندگان
چکیده
منابع مشابه
DNA Sequence Polymorphism of the Lactate Dehydrogenase Genefrom Iranian Plasmodium vivax and Plasmodium falciparum Isolates
BACKGROUND Parasite lactate dehydrogenase (pLDH) is extensively employed as malaria rapid diagnostic tests (RDTs). Moreover, it is a well-known drug target candidate. However, the genetic diversity of this gene might influence performance of RDT kits and its drug target candidacy. This study aimed to determine polymorphism of pLDH gene from Iranian isolates of P. vivax and P. falciparum. METH...
متن کاملdna sequence polymorphism of the lactate dehydrogenase gene¬from iranian plasmodium vivax and plasmodium falcipa¬rum isolates
background: parasite lactate dehydrogenase ( p ldh) is extensively employed as malaria rapid diagnostic tests (rdts). moreover, it is a well-known drug target candidate. however, the genetic diversity of this gene might influence performance of rdt kits and its drug target candidacy. this study aimed to determine polymorphism of p ldh gene from iranian isolates of p. vivax and p. falciparum. m...
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We have analysed the whole mitochondrial (mt) genome sequences (each ~6 kilo nucleotide base pairs in length) of four field isolates of the malaria parasite Plasmodium falciparum collected from different locations in India. Comparative genomic analyses of mt genome sequences revealed three novel India-specific single nucleotide polymorphisms. In general, high mt genome diversity was found in In...
متن کاملgenetic diversity in the circumsporozoite protein gene of plasmodium falciparum from major endemic regions of iran
circumsporozoite protein (csp) is one of the stage specific antigens, which is used for the development of vaccines and to investigate the genetic diversity in plasmodium falciparum malaria parasite. polymerase chain reaction was used for typing of csp genes on 67 positive falciparum malaria patients from sistan and baluchistan province of iran. three fragments were detected for csp gene. twent...
متن کاملTotal serum lactate dehydrogenase activity in acute Plasmodium falciparum malaria infection.
INTRODUCTION Lactate dehydrogenase (LDH) activity was assayed in the sera of 76 adult male and 76 adult female patients within the age group of 18-40 years presenting with acute, uncomplicated Plasmodium falciparum malaria infection and a control group of 80 healthy adults within the same age group. METHODS Patient selection and pre-qualification were done by simple random sampling of individ...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2018
ISSN: 1475-2875
DOI: 10.1186/s12936-017-2157-5